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Sunday, May 29

Orthopedic bone cements

Bone cements are polymeric materials that are extensively used for the fixation of components of arthroplasties. The materials are usually based on methylmetacrylate (MMA) monomer and a prepolymer powder, mainly poly(methyl methacrylate) (PMMA) that - after mixing - cure in situ. The cured cements are weight-bearing and load-transferring, and therefore their mechanical behavior plays a critical role in the implant outcome. Registry studies have shown that implant loosening often is related to cement failure (Espehaug, 2002; Havelin, 1995). Today, the clinical performance of new bone cements is basically revealed only by clinical registries of implant survival, as was the case with a bone cement using a new formulation (Boneloc).
The ultimate goal of this project is to identify parameters, as revealed by preclinical testing that can predict clinical outcome of bone cements. The aims are:

  • To investigate the time-dependent mechanical properties of a commonly used bone cement
  • To assess the influence of testing conditions on the mechanical behavior of cements
  • To characterize bone cement retrieved from revision operations